Download Advances in Nutritional Research: Volume 5 by Robert H. Bower, Josef E. Fischer (auth.), Harold H. Draper PDF

By Robert H. Bower, Josef E. Fischer (auth.), Harold H. Draper (eds.)

ISBN-10: 1461399394

ISBN-13: 9781461399391

Volume five of Advances in dietary study displays a powerful present curiosity within the dating among meals and illness. The effect of ailment on dietary prestige is defined for hepatic encephalopathy and melanoma and for a number of diseases of hospitalized young children. The influence of food on illness is illustrated utilizing the examples of retinol in tumorigenesis, supplements A and E in inflammatory lung disorder, fatty acids in atherogenesis and weight problems, and folate in megaloblastic anemia. The contents should be of specific curiosity to clinicians and to scholars of dietary biochemistry. vii Contents bankruptcy 1. dietary administration of Hepatic Encephalopathy ... Robert H. Bower and Josef E. Fischer 1. advent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. the character of Hepatic Encephalopathy. . . . . . . . . . . . . . . . . . . . . . . . 2 2.1. The Ammonia thought . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.2. The Amino Acid Neurotransmitter proposal. . . . . . . . . . . . . . . three three. dietary help in Hepatic Insufficiency. . . . . . . . . . . . . . . . . . . . 6 three. 1. healing Implications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3.2. healing thoughts. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 four. Experiments in Animals. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 five. event with sufferers in Hepatic Encephalopathy . . . . . . . . . . . . . 7 5.1. Acute Hepatic Encephalopathy . . . . . . . . . . . . . . . . . . . . . . . . . 7 5.2. persistent Hepatic Encephalopathy........................ nine References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . nine bankruptcy 2. mobile Retinol-and Retinoic Acid-Binding Proteins... thirteen Frank Chytil and David E. Ong 1 . advent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . thirteen . . . . . . . . . . . . . . 2. mobile Retinol-and Retinoic Acid-Binding Proteins . . . . . . . . . . thirteen . 2.1. Detection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 . . . . . . . . . . . . 2.2. features . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 . . . . . . . . . . . three. Binding Proteins in Cultured Cells . . . . . . . . . . . . . . . . . . . . 19 . . . . . . . four. Binding Proteins in Tumors. . . . . . . . . . . . . . . . . . . . . . . . 23 . . . . . . . . . 4.1. Binding Proteins in Experimental Tumors . . . . . . . . . . . . . 23 . . . 4.2. Binding Proteins in Human Tumors . . . . . . . . . . . . . . . . 23 . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 . . . . . . . . . . . . . . ix x Contents bankruptcy three. nutrients and 3-Methylindole-lnduced Lung damage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 . . . . . . . . . . . . . .

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Sample text

Significant binding occurred in the lung of goats, cattle, and horses and in the liver of hamsters. No binding occurred in the kidney of any 44 James A. Carlson and Tammy M. Bray species studied or in the lung of hamsters or monkeys (Hammond and Carlson, 1980b). Results of covalent binding experiments indicate that reactive intermediates are formed during MFO metabolism of 3MI. The binding can be altered by various MFO inhibitors or conjugating agents and the extent of binding generally reflects the organ and species specificity of 3Ml toxicity.

D s:: '< 3 3 Ill --t a. ::J Ill ::J 0 (j) 0 ~ ::0 en

5 and 2 hr respectively, manyfold less than concentrations required to cause direct membrane damage. Similarly, low 3MI concentrations in other tissues and organs confirmed that 3MI does not accumulate in significant quantities in any organs and tissues of goats after dosing. In contrast to low concentrations of labeled 3MI in the lungs, the amount of total radioactivity was equivalent to at least 50-fold the 3MI concentration in the lung, thus demonstrating the presence of metabolites. The lung contained more radioactivity than the liver and plasma at all times and contained more residual activity 24 hr after dosing.

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