By C. Gordon Zubrod (auth.), Alan C. Sartorelli, David G. Johns M. D. (eds.)
Over the earlier 20 years a few makes an attempt were made, with various levels of good fortune, to assemble in one treatise to be had info at the uncomplicated and utilized pharmacology and biochemical mechanism of motion of antineoplastic and immunosuppressive brokers. The logarithmic progress of information during this box has made it increasingly more tough to do justice to all features of this subject, and it truly is attainable that the current guide, greater than 4 years in education, could be the final try and survey in a. unmarried quantity the total box of gear em ployed in melanoma chemotherapy and immunosuppression. Even within the current example, it has proved worthwhile for functional purposes to submit the cloth in components, even supposing the plan of the paintings constitutes, at the least within the editors' view, a unmarried built-in remedy of this examine zone. a couple of components have contributed to the continual enlargement of study within the parts of melanoma chemotherapy and immunosuppression. lively compounds were rising at ever-increasing charges from experimental tumor screening platforms maintained by way of numerous inner most and governmental laboratories via out the realm. on the molecular point, wisdom of the modes of motion of estab lished brokers has persevered to extend, and has accepted rational drug layout to playa considerably higher function in a technique which, in its early years, depended nearly thoroughly upon empirical and fortuitous observations.
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Additional info for Antineoplastic and Immunosuppressive Agents Part I
The effectiveness of therapy in producing tumor-free survivors may be measured at a series of inoculum concentrations. It has been demonstrated in such studies that the ability of an agent to produce tumor-free survivors may be influenced by a variety of factors including the number of tumor cells present, the schedule of therapy, the degree of metastases and the extent of intracranial disease (GOLDIN, 1969). An empirical approach is featured in much of the investigations in which each form of therapy is tested to determine whether it is capable of producing a greatly improved result.
The processes for identification of useful drugs and determination of optimal modalities undergo progressive development. Where laboratory rather than clinical disease is used for screening and evaluating drugs and drug therapies, research should also be of a progressive nature, with test animals being regarded as representative of patients for whom it is desired to achieve the best possible therapy. , 1967; GOLDIN, 1968; GOLDIN and CARTER, in press). In working with experimental tumor-bearing mice a major obstacle to effective chemotherapy has been the toxicity of the host of the agents employed.
Lack of bone marrow toxicity, also upgrades interest in moving a drug forward in clinical trial. If acceptable activity, taking into account the above characteristics, is demonstrated in any of the signal tumors, Phase III trial is begun. This is a definitive study designed to establish the role of the drug in the armamentarium of the clinical oncologist. Discussion of these later trials is outside of the scope of this chapter. The determination of clinical activity for the six signal tumor types and its correlation with the experimental screen depends significantly on the definition of an adequate trial for a new antitumor agent.