Download Atherosclerosis Drug Discovery by M. R. Malinow, Phyllis McLaughlin, Lynne Papworth, H. K. PDF

By M. R. Malinow, Phyllis McLaughlin, Lynne Papworth, H. K. Naito, Lena Lewis (auth.), Charles E. Day (eds.)

ISBN-10: 147579309X

ISBN-13: 9781475793093

Although atherosclerosis is the best reason for demise within the so-called prosperous societies, there's shortly no drug in our pharmacologic armamentarium opposed to disorder to both hinder or opposite this insidious killer and debilitant of human lives. due to this void the 1st Brook inn Symposium on Anti­ Atherosclerosis Drug Discovery was once convened at Brook inn in Augusta, Michigan, August 13-15, 1975. The symposium used to be backed by way of The Upjohn corporation and was once foreign in scope, with investi­ gators attending from such nations as England, Japan, Belgium, and Italy. The symposium thinking about the issues linked to the invention and assessment of recent medicinal drugs potent in fighting or reversing atherosclerosis. The thrust of fabric is headquartered round animal types valuable as instruments within the seek and review of recent medications. largely categorised, the versions are nonhuman primates, rabbits, rodents, quail, and tissue tradition. the fabric is a mixture of reports on serum lipids and, extra importantly, of stories at the artery, regardless of serum lipid degrees. The prevention of arterial lesions, now not relief of serum lipids, is emphasised. A overview of all anti-atherosclerotic brokers, apart from hypolipidemic brokers, is incorporated during this quantity of the court cases of the symposium.

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In: Pathology of Simian Primates. Ed. N. T-W-Fiennes, Karger, Basel, pp. 756-808. 2. R. A. Maruffo. 1965. Naturally-occurring atherosclerosis in howler monkey (A1ouatta caraya). J. Atherosc1er. Res. 6:368-380. 3. R. A. Storvick. 1968. Spontaneous coronary lesions in ho~ler monkeys (A1ouatta caraya). J. Atherosc1er. Res. 8:421-431. 4. , A. A. McLaughlin. 1968. The effects of pyridino1carbamate on induced atherosclerosis in monkeys. J. Atherosc1er. Res. ~:455-561. 5. B. C. O. Goodman. 1971. Genetic control of plasma cholesterol: Studies on squirrel monkeys.

Atherosc1er. Res. 1:93-100. 27. A. P. Asper, Jr. 1955. Biological activity of compounds structurally related to thyroxine. Physio1. Rev. 35:426-474. 28. R. 1964. Thyroidal influence on experimental cholesterol atherosclerosis. Am. J. Path. 45:21-39. 29. L. Moynihan, J. A. L. Sachs. 1961. 5,3"-triiodo-thyronine on development and regression of experimental atherosclerosis in rabbits. J. Atherosc1er. Res. 1:211-221. 30. D. E. Connor. 1970. Regression of coronary atheromatosis in rhesus monkeys. Circ.

1% diet (Table VI). The lack of statistical significance is probably due to the small number of animals studied and to the fact that, as a consequence, only two groups were considered. 5%) for 6 Months TABLE VII 28 + 6 Coronary atherosclerosis (% encroachment of lumen) (l)Cornwell and Kruger, J. Lipid Res. 2:110-134, 1961 (dextran sulfate precipitation). 1. 181 + 7 6 No. ) A MODEL FOR THERAPEUTIC INTERVENTIONS 23 1+ 2+ 3+ 4+ 5+ FIGURE 13 Aortas from M. 5% diet for 6 months (2+ through 5+) and from a cynomolgus monkey on standard laboratory chow (1+).

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